Copyright © 2014 by ASME.In this study, three-dimensional computational fluid dynamics (CFD) analyses are performed to assess the thermal-hydraulic characteristics of a commercial Gasketed Plate Heat Exchangers (GPHEx) with 30 degrees of chevron angle (Plate1). The results of CFD analyses are compared with a computer program (ETU HEX) previously developed based on experimental results. Heat transfer plate is scanned using photogrammetric scan method to model GPHEx. CFD model is created as two separate flow zones, one for each of hot and cold domains with a virtual plate. Mass flow inlet and pressure outlet boundary conditions are applied. The working fluid is water. Temperature and pressure distributions are obtained for a Reynolds number range of 700-3400 and total temperature difference and pressure drop values are compared with ETU HEX. A new plate (Plate2) with corrugation pattern using smaller amplitude is designed and analyzed. The thermal properties are in good agreement with experimental data for the commercial plate. For the new plate, the decrease of the amplitude leads to a smaller enlargement factor which causes a low heat transfer rate while the pressure drop remains almost constant.