Low-threshold spiking interneurons perform feedback inhibition in the lateral amygdala

Creative Commons License

Ünal Ç. T., Ünal B., Bolton M. M.

Brain Structure and Function, vol.225, no.3, pp.909-923, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 225 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1007/s00429-020-02051-4
  • Journal Name: Brain Structure and Function
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.909-923
  • Keywords: Basolateral amygdala, Somatostatin, Parvalbumin, Interneuron, Low-threshold spiking, Fast-spiking, Feedback inhibition, DENDRITIC CALCIUM SPIKES, RAT BASOLATERAL AMYGDALA, IMMUNOREACTIVE INTERNEURONS, GABAERGIC INTERNEURONS, SYNAPTIC-INTERACTIONS, PROJECTION NEURONS, LOCAL CIRCUITS, VISUAL-CORTEX, SOMATOSTATIN, PARVALBUMIN
  • TED University Affiliated: Yes

Abstract

© 2020, The Author(s).Amygdala plays crucial roles in emotional learning. The lateral amygdala (LA) is the input station of the amygdala, where learning related plasticity occurs. The LA is cortical like in nature in terms of its cellular make up, composed of a majority of principal cells and a minority of interneurons with distinct subtypes defined by morphology, intrinsic electrophysiological properties and neurochemical expression profile. The specific functions served by LA interneuron subtypes remain elusive. This study aimed to elucidate the interneuron subtype mediating feedback inhibition. Electrophysiological evidence involving antidromic activation of recurrent LA circuitry via basolateral amygdala stimulation and paired recordings implicate low-threshold spiking interneurons in feedback inhibition. Recordings in somatostatin-cre animals crossed with tdtomato mice have revealed remarkable similarities between a subset of SOM+ interneurons and LTS interneurons. This study concludes that LTS interneurons, most of which are putatively SOM+, mediate feedback inhibition in the LA. Parallels with cortical areas and potential implications for information processing and plasticity are discussed.