Longitudinal Associations of Experienced and Perceived Community Stigma with ART Adherence and Viral Suppression in New-to-care People with HIV: Mediating Roles of Internalized Stigma and Depression Symptoms


Yiğit İ., Turan B., Kurt G., Weiser S. D., Johnson M. O., Mugavero M. J., ...Daha Fazla

JAIDS : JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, cilt.95, sa.3, ss.231-237, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1097/qai.0000000000003360
  • Dergi Adı: JAIDS : JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, MEDLINE, Public Affairs Index, Veterinary Science Database
  • Sayfa Sayıları: ss.231-237
  • TED Üniversitesi Adresli: Evet

Özet

Background: While cross-sectional studies have suggested that HIV-related stigma and depression symptoms may result in poor HIV treatment and health outcomes, few studies have investigated potential longitudinal mechanisms in these relationships. Furthermore, longitudinal effects of HIV-related stigma on health outcomes have not been examined in people with HIV (PWH) newly initiating HIV clinical care. We examined longitudinal associations between experienced and perceived community stigma and health outcomes (ART adherence and viral load), mediated by internalized stigma and depression symptoms among new-to-care PWH in the United States. Setting /Methods: Data were obtained from 371 PWH who initiated HIV medical care at four HIV sites at baseline and 48 weeks later between December 2013 and 2018. Validated measures were used to assess experienced stigma, perceived community stigma, internalized stigma, depression symptoms, and ART adherence; and viral load was obtained from medical records at final study visit. Results: Serial mediation models revealed significant indirect effects of experienced stigma and perceived community stigma on ART adherence and on viral suppression, first through internalized stigma, and then through depression symptoms. Conclusions: These results suggest that PWH may tend to internalize HIV-related stigma when they experience acts of stigmatization or perceive negative attitudes in society, which in turn may result in negative effects on psychological and physical well-being. These findings about how stigma in society may be an antecedent mechanism for PWH to develop internalized stigma, which in turn affects individual health outcomes, can be used to tailor both individual-level and community-level interventions.