© Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.Stigma in health care settings can have negative consequences on women living with HIV, such as increasing the likelihood of missed visits and reducing trust in their clinical providers. Informed by prior stigma research and considering knowledge gaps related to the effect of patient-provider race concordance, we conducted this study to assess if patient-provider race concordance moderates the expected association between HIV-related stigma in health care settings and patients' trust in their providers. Moderation analyses were conducted using Women's Interagency HIV Study data (N = 931). We found significant main effects for patient-provider race concordance. Higher experienced stigma was associated with lower trust in providers in all patient-provider race combinations [White-White: B =-0.89, standard error (SE) = 0.14, p = 0.000, 95% confidence interval, CI (-1.161 to-0.624); Black patient-White provider: B =-0.19, SE = 0.06, p = 0.003, 95% CI (-0.309 to-0.062); and Black-Black: B =-0.30, SE = 0.14, p = 0.037, 95% CI (-0.575 to-0.017)]. Higher anticipated stigma was also associated with lower trust in providers [White-White: B =-0.42, SE = 0.07, p = 0.000, 95% CI (-0.552 to-0.289); Black patient-White provider: B =-0.17, SE = 0.03, p = 0.000, 95% CI (-0.232 to-0.106); and Black-Black: B =-0.18, SE = 0.06, p = 0.002, 95% CI (-0.293 to-0.066)]. Significant interaction effects indicated that the negative associations between experienced and anticipated HIV-related stigma and trust in providers were stronger for the White-White combination compared with the others. Thus, we found that significant relationships between HIV-related experienced and anticipated stigma in health care settings and trust in providers exist and that these associations vary across different patient-provider race combinations. Given that reduced trust in providers is associated with antiretroviral medication nonadherence and higher rates of missed clinical visits, interventions to address HIV-related stigma in health care settings may improve continuum of care outcomes.